Denestra SAMe 400 mg (60 Tablets)
Item: SAME400MG60
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Description
Denestra SAMe is a dietary supplement that contains S-Adenosylmethionine (SAMe), a naturally occurring compound found in the body. SAMe plays a vital role in various biochemical processes, including the production of neurotransmitters and the maintenance of cell membranes.
Key Benefits:
- Liver Health: SAMe is known for its positive effects on liver health. It supports the production of glutathione, a powerful antioxidant that helps protect liver cells from damage caused by toxins, medications, and oxidative stress.
- Mood and Emotional Well-being: SAMe is involved in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are crucial for regulating mood and emotions. Supplementing with SAMe may help improve mood, reduce anxiety, and alleviate symptoms of depression.
- Joint Health: SAMe has anti-inflammatory properties that can help reduce joint pain and inflammation. It is often used as a complementary therapy for conditions like osteoarthritis, where it can support joint mobility and promote overall joint health.
- Cognitive Function: SAMe is believed to have neuroprotective properties and may help support cognitive function and memory. It is being investigated for its potential benefits in conditions such as Alzheimer's disease and age-related cognitive decline.
- Energy and Vitality: SAMe is involved in the production of adenosine triphosphate (ATP), which is the body's primary energy source. By supporting ATP production, SAMe may help improve energy levels, promote vitality, and reduce fatigue.
It's important to note that individual results may vary, and it's always recommended to consult with a healthcare professional before starting any new dietary supplement.
Specifications:
- Pet Life Stage: Adult, Senior
- Food Form: Supplement
- Breed Size: Small Breeds, Medium Breeds, Large Breeds, All Breeds, Giant Breeds, Extra Small Breeds
- Product Form: Tablet
- UPC: 814087006073
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Uses
Denestra with SAMe supports liver metabolic activity and proper liver function for dogs and cats. SAMe, or S-Adenosyl-Methionine, is a naturally occurring substance found in all living beings. SAMe in its biological form contributes to better pet health through a number of chemical processes: transmethylation, transsulfuration, and aminopropylation. |
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Benefits
These processes can affect liver and joint health in animals. Through the process of transsulfuration, natural SAMe is converted into a compound called glutathione, a potent antioxidant and liver detoxification tool. It supports normal detoxification and cleansing of the liver from impurities, which in turn may help the body from exposure to heavy metal or environmental toxins. |
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Additional Benefits
Denestra with naturally occurring SAMe has added benefits for pet joint health as well. During the aminopropyl ation process, methylthioadenosine (MTA) is produced. MTA helps support cartilage matrix production in the joints, and may help maintain the effectiveness of proteoglycans, molecules that are critical for the lubrication of joints. |
Ingredients
Ingredients:
S-Adenosyl-L-methionine disulfate p-toluensulfonate, Microcrystalline cellulose, Mannitol, Carboxymethylstarch sodium salt, Colloidal silica anhydrous, Glycerol behenate, Magnesium stearate.
Coating Ingredients:
Methacrylic acid copolymer, Glycerol palmitostearate, Medium chain triglycerides, Titanium dioxide, Colloidal silica anhydrous, Talc, Triethyl citrate, Yellow iron oxide (III).
Useful Information
| Administration | |
|---|---|
| Animal Weight | Daily |
| Less than 15 lbs. | 1 Tablet |
| 16-35 lbs. | 2 Tablets |
Denestra® should be administrated on an empty stomach, one hour before or two hours after a meal (overnight fast is preferred). Do not cut or crush tablets. May be disguised in treats for easier administration. Dosage may be increased or decreased at any time at the recommendation of your Veterinarian.
CAUTIONS:
If animal's condition worsens or does not improve, stop product administration and consult your Veterinarian. In case of accidental overdose, contact a health professional immediately.
WARNINGS:
For use in animals only.
STORAGE:
Store in a cool dry place. Keep out of reach of children and pets. Keep tablets in their original blister pack until used. Tablets are sensitive to moisture and extreme heat.
Customer Reviews
Review Summary
4.6
26 Reviews
5
73% (19)
4
19% (5)
3
4% (1)
2
4% (1)
1
0% (0)
92% Recommend this product (24 of 26 responses)
By PartyofFive
Big pills
October 5, 2023
These pills are larger than expected and not so easy to give to my picky dog. I tried adding it to her food and I noticed she would eat around it. Tried giving it to her in cheese, nope. My next option was pill pockets and she took them, no issues. She's been on them for about a month now and I haven't seen much of a difference. Will continue and update on the progress.
* This product review was collected by the manufacturer.
By oscar f.
IN
Quality
September 23, 2023
Great product and service and shipping.
By HeyNay
Excellent Senior Pup Supplement
September 17, 2023
This promotes healthy liver function by detoxifying harmful substances which seriously provides me with peace of mind for my senior pups health.2 of my 3 senior pups have other medical conditions, but I'm grateful this has been safe to use alongside their other prescribed medications. The NASC seal is something I specifically look for and want when purchasing my babies' supplements as it reassures me of its quality.Denestra will become a part of my senior pup's healthcare regimen, and I highly recommend it to senior pet parents.
* This product review was collected by the manufacturer.
By Lucky G.
Good supplement with many benefits for pets
September 6, 2023
The S-Adenosyl-L-Methionine supplement was exactly as advertised and provides all the health benefits to my pets in the product description. It is a great product for pets and a good value for all the benefits it provides.
* This product review was collected by the manufacturer.
By Justadogmom
Seems to help
August 29, 2023
I've been giving my dog these pills for several weeks now.I thought I was giving it to her longer but then I started finding the pills where she had spit them out. Silly girl.Now that I am sure it is in her system now, I feel like it has made her more alert, and more active.Which tells me that the inflammation and pain she's had is easing up.I'm really happy for my dog to be back to doing her silly goofy self.Anyway
* This product review was collected by the manufacturer.
By Heidilyn
Denestra Great value for SAMe, seems to be very effective for aging Doberman.
August 29, 2023
I wish cats were so easy to work with when hiding pills or meds in food. This SAM e is great. No problems with use, Max has had no nausea or gastric issues. The inflammation and joint pain is reduced and his mood is much better. He seems happier. Far less barking at night and a better time with getting up and laying down, comfortably. He's big but showing some signs of aging in his hips and back legs, as well as his mood. He's been more irritable with outside noises, people walking by over the last year. He's a bit more jumpy. After about 3 weeks, he is doing much better. He'll eat the tablets with peanut butter, hot dog, turkey sandwich, and managed to eat around it when left in his dinner bowl.This seems to be an authentic product and did not take long to show effects.5 stars
* This product review was collected by the manufacturer.
By L H.
Great supplement!
August 24, 2023
I had been wanting to try SAMe for my dogs, and so was glad to find this product. What I like about this particular brand is that it's made in the USA and the tablets are in airtight foil packs, so oxygen can't degrade the ingredients. I am super satisfied knowing that these ingredients are now a part of their diet, after doing a lot of research on SAMe.
* This product review was collected by the manufacturer.
By TM
Nice
August 20, 2023
I cant really say anything to the effectiveness honestly. My lab takes these but has to have it disguised in his food. I think the value for the pricepoint is great!
* This product review was collected by the manufacturer.
By john K.
We'll see
August 14, 2023
Our dog has only been using this product for a short time. He looks like he's feeling better and isn't hurting. Since starting this, he seems to be more mobile and even has started rough-housing with the other dogs. I highly recommend!
* This product review was collected by the manufacturer.
By Melissa
Pill is pretty big
August 6, 2023
The pill had to be crushed because it was big and my dog will not eat. Needs to be smaller and good smelling and tasting for them .
* This product review was collected by the manufacturer.
By Vale P.
I got this for my senior Doxie.
August 4, 2023
This is an awesome product, however I didn't see the dig had to be at least 33lbs and you can't cut or crush the pill. So I will be giving to a neighbor for her old big dog.
* This product review was collected by the manufacturer.
By D D.
Dog tolerates, so far, so good
August 4, 2023
Have been giving these to our ten year old Akita. She refuses 90% of the supplements I have tried with her, but these, wrapped in cream cheese, she will accept. That's a huge head start compared to the others. I have no idea if the are beneficial—a week is too soon, but it does give me an opportunity to discern if there are any immediate side effects, so far none. If positive effect is observed, I'll report back joyfully.
* This product review was collected by the manufacturer.
By celestetfelice
Dog supplements
August 3, 2023
As described.Denestra - for Dogs - S-Adenosyl-L-Methionine -supolements to help Dogs Liver, Joints and Cognitive Support. for Larger Dogs size tablets- Veterinarian Approved - 400 mg - 60 Tab box..I ordered these for our geriatric doggos-3 of them.i have to split them in half as each dog is under 25 lbs.they fought us trying to pill them.but we got them down.i noticed some stomach upset the next day,loose stools.im sure this will pass as the dosage accumulates in their bodies.
* This product review was collected by the manufacturer.
By Melissa C.
good addition to my dog's diet
August 3, 2023
Only time will tell if these make a difference. My dog gobbles them down though, which is a blessing. Usually, we a problem with him taking anything new. My vet suggested a joint supplement and I checked with her about these and she said they we be fine. Decent price compared to most brands.
* This product review was collected by the manufacturer.
By Joanna D.
Brain and joints
August 2, 2023
A supplement that is supposed to help with doggy dementia. Like us, dogs can get mentally dull with age. And their joints get stiff. My dog is still as clever as ever, but her joints are very stiff. She gets glucosamine but anything to keep her feeling sharp and limber....we'll give it a go.Beware that this supplement can cause diarrhea, so go slowly at first until the dog's tummy adapts. Some dogs have more sensitive guts than others. And unlike us, we might run to the loo but they'll cut loose if they need to and that is NOT fun.
* This product review was collected by the manufacturer.
By Typical A.
GET IT FOR THE RIGHT SIZE
August 2, 2023
Alright, let me set the record straight. I messed up and got this supplement for my teeny tiny 17-year-old senior dog. Yeah, not the intended audience, but hey, I'm still giving it 5 stars 'cause the instructions are pretty clear and honest.So, here's the deal. If you're thinking of getting this for a smaller pooch and breaking or cutting the pill, don't do it! The instructions and some online studies say that a broken pill might not work as intended since it needs that outer shell to protect it from the digestive tract. So, get the right size for your doggie. The smallest allowed is 35 pounds, double my small dog's size.I know, I know, I saw " for larger dogs" on the label, and I thought I could outsmart it. Nope, the label's right, and I was wrong.Just make sure you read those labels properly and get the right size for your fur baby. Lesson learned
* This product review was collected by the manufacturer.
By Gianni B.
High SAMe Dosage Without Silybin (Milk Thistle)
July 21, 2023
This review is for Denestra - Same for Dogs - S-Adenosyl-L-Methionine - Dog Liver, Joint and Cognitive Support for Larger Dogs - Veterinarian Approved - 400 mg - 60 Tabs. This pill reminded us of Denamarin (without the Silybin) but seems to be just as effective when used in conjunction with milk thistle. We've used Denamarin for large dogs for several months but we couldn't get our dog to take it without a lot of struggle so we were forced to find an alternative solution. He could smell the huge blue pill inside a pill pocket (or any treat) and would not open his mouth to take it. However, he didn't flinch with these Denestra pills so we're really happy with them. What a relief! Our alternative solution to Denamarin was to use SAMe in conjunction with Milk Thistle for the Silybin/Silymarin, and he's been doing really well on them. The only problem is that we have to give him several SAMe pills per day as opposed to just one pill now. Denestra has 400 mg of SAMe per pill vs our old SAMe which was ~56 mg per pill (i.e. 225 mg for 4 pills). Overall, we're really pleased with these pills and we have not seen any adverse effects on our dog since switching to Denestra. We'll be going in for his checkup next month so will know for sure then if anything changes. For now, these pills seem to be just as effective for us when used in conjunction with milk thistle. It would be more convenient to administer with Silybin already added (like Denamarin) though, but we've managed it so far. We'd give it a 4.8/5.0 - 07/21/2023.
* This product review was collected by the manufacturer.
By Lisa
Iowa
Really works
May 26, 2023
Our four legged baby is closing in on thirteen years old. About a year and a half ago she went on Meloxicam for her arthritis. It was not long before she started to have her liver test results increase from the NSAID. After doing some research and discussing with her vet, we put her on 400mg of SAM-e twice a day (dosage associated with her weight). There was a positive impact to her liver test results and it has continued to help her with that issue ever since.
Wished I’d known it was out there sooner, we would have started her on it even before she needed the Meloxicam.
Wished I’d known it was out there sooner, we would have started her on it even before she needed the Meloxicam.
Pros
- It does work
Cons
- It is a bit pricey, but I always get it when it’s on sale so that helps.
- The 400mg pills are of course larger, but I only have to give her one, twice a day that way.
By Dermot T.
My dog had only been on it 3 wks. ...
August 15, 2016
My dog had only been on it 3 wks. It's hard to say. I read some reviews & it states it might take up to 6 wks before the pills work.Our Bassett is 12 yrs old & very much old for her breed.She still wanders
* This product review was collected by the manufacturer.
By Micki
Lake Tahoe
Difficult to administer
May 9, 2016
I cannot speak for the medical effectiveness of this product. I hope that it is worth the trouble of getting my Standard Poodle to take it. He is usually very compliant with meds or anything we ask him to do. But he seems to hate the taste and smell of this drug. Hiding it in peanut butter or other treats does not work. He can smell it and knows what is coming. Hopefully "Entirely Pets" can ask the drug company to improve the recipe. I am not sure how many more pills I can get into him before we all give up.
By Sally
Okotoks, Alberta, Canada
Amazing Results
May 7, 2016
My 11 Siberian Husky Toby had extremely high ALT Liver values. After conducting research, I decided to try SAMe (Denestra) for this serious medical issue. 1.5 years later I am happy to report that Toby's liver values are in the normal range and he is happy and healthy. Very grateful for this wonderful product
By Susan
Cave Creek, AZ
Great price
January 29, 2016
Two of my dogs had high liver enzymes and were prescribed Adenosyl which was very expensive through my Vet's office. I researched prices online and discovered Entirely Pets and even confirmed that Denestra was the same product. I've been very happy with getting a much more affordable price and how easy it is to reorder and get delivery.
By Mandy L.
Mesa, AZ
Great Product!
April 21, 2014
Started giving these to our 15 year old Chow approximately 1 month ago and she has shown major improvement in her mobility. She seems like she is much happier and enjoys short walks which she hadn't done in years. I recommend NOT using Greenies pill pockets with this product as my experience was that they prevented the Denestra pill from dissolving and eventually caused vomiting of days worth of pills. I'm not sure if it's the combination of the two products or the fact that from what I've read on-line Greenies are all around bad. I've had success with a spoonful of peanut butter.
By Mandy L.
Mesa, AZ
Works Great!
March 26, 2014
We have a 14 year old Chow Chow who was acting very sluggish, depressed, and stiff in the joints. After only 2 days we see improvement in all areas. Hopefully it's long term!
By nicky
new zealand
Great product
July 24, 2013
This has helped reduce my old dogs elevated liver enzyme levels by over 1/2. Very happy with it & will continue to use it.
By froglady
Denestra
May 31, 2013
This product is great for our dog. And the bubble packaging keeps it fresh and ready to go.
Questions and Answers
2 Questions &
2 Answers
January 25, 2019
My dog is 125 pounds. He’s a large breed. I am confused on the dosing. Do I give him 3 pills at once, or do I give him 1 pill, 3 times per day?Â
1 Answer
Administration
Animal Weight Daily
35-65 lbs. 1 Tablet
66-99 lbs. 3 Tablets
Over 100 lbs. 3 Tablets
Submitted by:
EntirelyPets
on April 29, 2019
Ann
from Burlington NC asked:
July 25, 2017
What is the difference between Dnestra SAME and Denamarin Do they both serve the same purpose?
1 Answer
Denestra (SAMe) is pure SAMe great for liver function.
Denamarin includes SAMe + a small amount of Silybin A+B.
Silybin is a milk thistle extract, also known to be good for liver function.
They are both good, and both have had great customer feedback for dogs with liver issues.
Submitted by:
Customer Service
on July 1, 2019
 Denestra SAMe 200 mg (60 Tablets)Reg price: $51.99Sale price: $39.59 |  3-PACK Denestra SAMe 200 mg (180 Tablets)Reg price: $151.99Sale price: $116.79 |  3-PACK Denestra SAMe 400 mg (180 Tablets)Reg price: $190.99Sale price: $146.49 |  Denestra SAMe 100 mg (60 Tablets)Reg price: $32.99Sale price: $24.99 |