12 MONTH K9 ADVANTIX Red (for dogs 21-55lbs)

Q: How long does K9 Advantix last?

A: A single application of K9 Advantix keeps working for one month.

Q: How often should customers use K9 Advantix?

A: Experts recommend that pet owners should apply monthly to keep their dogs protected year round.

Q: My pet is strictly indoors. Should I still use Advantage?

A: Yes, Ticks and fleas can be brought into the home by people or other pets without pet owners even realizing it. Immature flea stages remain dormant until conditions are appropriate for development and infest pets after hatching. That's why it is important to also protect indoor pets.

Q: Can I bathe my pets during the month after application?

A: Yes, you can give your dogs or cats a bath. We recommend a non-detergent shampoo for best results.

Q: For what age pets can I use K9 Advantix on?

A: K9 Advantix is gentle enough for puppies as young as 7 weeks.

Precautionary Statements Hazards To Humans Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Wash hands thoroughly with soap and warm water after handling.

Hazards To Domestic Animals *For external use on dogs only. *Do NOT use on animals other than dogs. *Do NOT use on puppies under seven weeks of age. Do not get this product on the dog's eyes or mouth. as with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing animals. Individual sensitivities, while rare, may occur after using ANY pesticide product for pets. If signs persist or become more severe, consult a veterinarian immediately. If your animals are on medication, consult your veterinarian before using this or any other product.

DO NOT USE ON CATS Due to their unique physiology and inability to metabolize certain compounds, this product must not be used on cats. If applied to a cat, or ingested by a cat which actively grooms a recently treated dog, this product may have serious harmful effects. If this occurs, contact your veterinarian immediately.

Environmental Hazards This product is extremely toxic to fish. Do NOT add directly to water. Do NOT contaminate water when disposing of product or package.

First Aid Have the product container or label with you when calling a poison control center or doctor, or going for treatment.

If in eyes: Hold eye open and rinse slowly and gently with water for 15 - 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice.

If swallowed: Call poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do NOT induce vomiting unless told to do so by the poison control center or doctor. Do NOT give anything by mouth to an unconscious person.

If on skin or clothing: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15 - 20 minutes. Call a poison control center or doctor for treatment advice.

To Physician: Treat the patient symptomatically.

K9 Advantix kills fleas and ticks on Dogs K9 Advantix for dogs is effective flea and tick treatment for dogs. When a flea is exposed to imidacloprid on a treated pet, the compound is absorbed through the insect's intersegmental membrane. Here, the compound comes into contact with the flea's nervous system. Imidacloprid then acts inside the synapse of the insect to disrupt transmission of the nervous impulse. Imidacloprid binds to post-synaptic nicotinic receptor sites inside the synapse, essentially "locking" the receptor in the open position thus hyperstimulating the cell. As this occurs throughout the nervous system, it leads to death of the insect. Furthermore, imidacloprid is highly selective in its activity. It only binds to insect nicotinic receptor sites, showing virtually no affinity for mammalian receptor sites. As an analogy, one may think of a lock and key, where the insect nicotinic receptor site is the lock and imidacloprid is the key. Imidacloprid only "fits" the right "lock," and does not fit similar receptor sites found in mammals.

Why killing flea lavre is important Flea larvae live in the canine's environment on bedding, carpeting and anywhere the dog regularly sleeps or plays. By killing flea larvae in the canine's environment, imidacloprid kills potentially re-infesting fleas at the source, before they have a chance to reproduce to infest the pet and the home. This larvicidal activity in the environment, combined with the rapid adulticidal activity on the pet, eliminates existing flea infestations quickly and prevents new ones from developing, all without the use of environmental foggers, sprays, or insect growth regulators.

Larvicidal activity Imidacloprid is the premier flea control product, in large part, due to its unsurpassed adulticidal activity. However, imidacloprid also possesses significant larvicidal activity. In fact, Advantage, ® and now K9 Advantix, ® are the only flea adulticides that can make a larvicidal claim.

How imidacloprid kills flea larvae in the environment Once K9 Advantix Dog is applied, both active ingredients (imidacloprid and permethrin) spread across the body. Imidacloprid, in particular, spreads rapidly. During this process, imidacloprid forms very fine particles that bind with the superficial lipid layer on the skin surface. This lipid material is slowly shed off of the animal, via the normal replenishing activity of the epidermis. This "dander," made up of bits of epidermal cells, lipid, hair fragments and such, also contains imidacloprid. Thus, the treated dog, in essence, treats its own environment. As imidacloprid is an extremely potent compound (i.e., very small amounts kill fleas and flea larvae), sufficient amounts are deposited to effectively kill flea larvae in the pet's surroundings.

Inhibition of flea biting Studies conducted in Germany by Dr. Heinz Mehlhorn also demonstrate that imidacloprid possesses significant anti-feeding activity, and fleas that jump onto an imidacloprid-treated dog stop feeding in 3 to 5 minutes. Additional studies, conducted by Dr. Michael Rust at the University of California at Riverside, confirmed that imidacloprid demonstrates significant anti-feeding activity, even at very low doses. These results are significant as it is the feeding activity of fleas that elicits an allergic condition known as flea allergy dermatitis.

Activity of imidacloprid against ticks The highly specific mode of action of imidacloprid makes it an ideal compound for insect control. However, it does limit its utility against ticks and mites because they are arachnids (the same class as spiders) rather than insects. Research has shown that imidacloprid does not bind as well to arachnid receptors as it does to insect receptors. For this reason, imidacloprid is not utilized as a stand-alone ingredient for canine tick control. Rather, its limited activity against ticks is best exploited to enhance the efficacy of other compounds, permethrin in particular.