Merck Safe-Guard Equine Dewormer Paste, 25gm

Safe-Guard Equine Dewormer Paste Directions:

• Give Safe-Guard Equine Dewormer Paste by the mouth.
• Remove syringe tip.
• Turn the dial ring until the edge of the ring nearest the tip lines up with zero.
• Depress plunger to advance paste to tip.
• Now set the dial ring at the graduation nearest the weight of your horse (do not underdose).
• Insert the nozzle of the syringe in between your horse's teeth and deposit the paste on the back of the tongue by depressing the plunger.
• Safe-Guard Equine Dewormer Paste is administered orally at a rate of 2.3 mg/lb (5 mg/kg) for the control of large strongyles, small strongyles, and pinworms. One 25 gram syringe will deworm a 1,100 lb horse. For foals and weanlings (less than 18 months of age) where ascarids are a common problem, the recommended dose is 4.6 mg/lb (10 mg/kg); one 25 gram syringe will deworm a 550 lb horse.
• For control of encysted early third stage (hypobiotic), late third stage and fourth stage cyathostome larvae, and fourth stage larvae of Strongylus vulgaris, the recommended dose is 4.6 mg/lb (10 mg/kg) daily for 5 consecutive days; administer one 25 gram syringe for each 550 lbs body weight per day.

Storage:

Store at or below room temperature. Keep out of the reach of children and pets.

How does Safe-Guard Equine Dewormer Paste work?

Each gram of Safe-Guard Equine Paste Dewormer contains 100 mg of fenbendazole. The antiparasitic action of Safe-Guard Equine Paste Dewormer is believed to be due to the inhibition of energy metabolism in the parasite.

Cautions:

Side effects associated with Safe-Guard Equine Paste Dewormer could not be established in well-controlled safety studies in horses with single doses as high as 454 mg/lb (1,000 mg/kg) and 15 consecutive daily doses of 22.7 mg/lb (50 mg/kg). Particularly with higher doses, the lethal action of fenbendazole may cause the release of antigens by the dying parasites. This phenomenon may result in either a local or systemic hypersensitive reaction. As with any drug, these reactions should be treated symptomatically. Safe-Guard Equine Paste Dewormer has been evaluated for safety in pregnant mares during all stages of gestation and in stallions with doses as high as 11.4 mg/lb (25 mg/kg). No adverse effects on reproductivity were detected. The recommended dose for control of 4th stage larvae of Strongylus vulgaris, 4.6 mg/lb (10 mg/kg) daily for 5 consecutive days, has not been evaluated for safety in stallions or pregnant mares.